The Ten Commandments can be summed up with one phrase: All of lie is sacred - or all of life is holy. There is no sacred/secular divide in life because we were made in God's image and God is not divisible between sacred and secular. In fact, before the fall there was no secular, only sacred. With the fall, men and women made the choice to pursue their own way (secular) and from the fall God has been calling men and women back to His way (the sacred).
It is in that light that the Ten Commandments, the moral law makes the most sense starting with "You shall have no other Gods before me." There can be no competing God's in our lives for either we worship Him wholly or we don't. While there are many competing Gods that call our attention, our sacred devotion is to one alone. In fact, if we got this one right, the following nine commands would not be necessary!
We should not misuse God's name because He is Holy and therefor our speech is holy and sacred as well. We remember the sabbath (in principle) because how we spend our time is sacred. We honor our father and mother because that is where we learn to live under authority and ultimately to honor God. We do not commit murder because life is sacred, we don't steal because our actions are sacred and God provides what we need. We don't commit adultery because marriage is sacred or give false testimony because truth is sacred. We don't covet because even our thinking is sacred.
Learning to look at all of life from a sacred perspective is part of the re-imaging each of us need. God created us in His image, an amazing truth that is hard for us to get our hands around. That image has been badly tarnished by sin but God has been re-imaging us from the time of the fall, culminating in the death and resurrection of Christ. To be re-imaged is to once again see life from a sacred perspective, to walk in the ancient ways of holiness and to learn to view all of life from God's perspective. As we do so the Holy Spirit re-images us piece by piece, thought by thought, action by action, commitment by commitment.
God's desire is that His people would once again claim the sacredness of life. It is who He created us to be. It was His intention from the day of creation. It is what He is recreating through salvation and the outworking of the Gospel and it is what He will bring to fruition when Heaven comes Down to Earth and the two become one - completely re-imaged and remade to the original intent of the creator.